Access Proof of Concept Syngeneic, Xenograft, Orthotopic, and Humanized Models
Through a 10,000-square-foot AAALAC-accredited vivarium that is staffed with experts in preclinical oncology research, our clients have access to more than 300 human tumor and murine tumor cell line-derived models that represent all of the major histologies, as well as rare disease. As part of that collection, you can:
- Make Selection Easier: Many lines have been characterized using gene expression profiling data that can guide cell line selection.
- Diversify Model Sampling: In addition to traditional subcutaneous xenograft models, TD2 also offers tumor cell lines as orthotopic and metastatic models, and can incorporate imaging into these studies with available light-emitting cell lines.
- Get Clear Results: In vivo efficacy studies are designed to identify optimal and streamlined development strategies for your experimental agent—with endpoints of tumor growth inhibition (TGI), tumor growth delay (TGD/survival), imaging endpoints and biomarker analysis.
Get High-Tech Optimal Imaging Resources
Facilitate preclinical optical imaging with a multi-modal AMI 1000 designed for powerful bioluminescence, fluorescence and X-ray.
Glean Early Insights About Toxicity
Through non-GLP toxicology assessments—including dose range finding, pharmacokinetic analysis, CBC and blood chemistries, and highly sophisticated histopathology services—you can glean early insights into a drug's activity and toxicity, which can be added to any in vivo study as secondary endpoints.
Store and Access Data, Securely
Get accurate data collection and reporting through StudyLog®, our electronic data collection software—which also enables more reliable data collection and faster analysis. Access your data (individual/group mean tumor volumes, body weights, graphs, and observations) through our secure data room at any point through the study.