Access Proof of Concept Syngeneic, Xenograft, Orthotopic, and Humanized Models
Through a 10,000-square-foot AAALAC-accredited vivarium that is staffed with experts in preclinical oncology research, our clients have access to more than 300 human tumor and murine tumor cell lines that represent all of the major histologies, as well as rare disease. As part of that collection, you can:
- Make Selection Easier: Many lines have been characterized using gene expression profiling data that can guide cell-line selection.
- Diversify Model Sampling: In addition to traditional subcutaneous xenograft models, TD2 also offers tumor cell lines as orthotopic and metastatic models, and can incorporate imaging into these studies with available light-emitting cell lines.
- Get Clear Results: In vivo efficacy studies are designed to identify optimal and streamlined development strategies for your experimental agent—with endpoints of tumor growth inhibition (TGI), tumor growth delay (TGD/survival), imaging endpoints and biomarker analysis.
Get High-Tech Imaging Resources
Facilitate preclinical optical imaging with a multi-modal AMI 1000 designed for powerful bioluminescence, fluorescence and X-ray—coupled with spectral instruments for unmatched optical precision.
Glean Early Insights About Toxicity
Through non-GLP toxicology assessments—including dose range finding, pharmacokinetic analysis, CBC and blood chemistries, and highly sophisticated histopathology services—you can glean early insights into a drug's activity and toxicity, which can be added to any in vivo study as secondary endpoints.
Store and Access Data, Securely
Get an immediate and accurate method of real-time data reporting through StudyLog, our electronic data collection software—which also enables more reliable data collection and faster analysis. Access your data (individual/group mean tumor volumes, body weights, graphs, and observations) through our secure data room at any point through the study.