Bioanalytical Services

Assess quantitative analyses of small and large molecules—and possible metabolites—through our Pharmacokinetic Laboratory (PK lab), which offers:

  • Bioanalytical method development and transfer under a non-GLP environment, with proper evaluation based on FDA guidance parameters (linearity, sensitivity, accuracy, stability and recovery)
  • Highly-sensitive instrumentation that conducts analyses via LC-MS/MS equipment (Waters Xevo TQ-S coupled with Acquity I-class UPLC system)

The DMPK Lab

Have every confidence that your sample analyses and results are protected, robust and accurate. From there, in vivo portions of pharmacokinetic studies are conducted and then easily transferred to our co-located bioanalytical facility.

Exclusive features now available:

  • Therapeutic Drug and Dose Adjustment: Access dose-guided therapeutic drug and dose adjustment, as well as early screening and Proof of Concepts (POC) for small and large molecules of interest.
  • Compound Kinetics: Combining early chemistry with POC xenograft models, we provide alignment of compound kinetics from in vitro metabolism through PK and PD studies. 
  • Expert Research Analysis: Our oncology research experts conduct pharmacokinetic and toxicokinetic analysis through the Phoenix WinNonlin.

In vitro assays now available:

  • Physiochemical properties
    • Chemical stability in simulated fluids
  • Metabolism
    • Metabolic stability: S9 fractions, microsomes, hepatocyte
    • CYP inhibition using microsomes or recombinant enzymes (supersomes)
    • CYP inhibition – High throughput screening 
    • Plasma stability
    • CYP/UGT reaction phenotyping
  • Permiability
    • PAMPA
    • Caco-2 permeation studies
  • Protein binding
    • Tissue binding
    • Blood to plasma ratio
    • Plasma protein binding
      • RED
      • Ultrafiltration
  • Bioanalysis
    • Bioanalytical method development and validation
    • Pharmacokinetic analysis (PK)
    • Tissue distribution
    • Analysis of large molecules
    • Dried Blood Spot (DBS) analysis
    • Dose Configuration
      • LC-MS/MS
      • UV-VIS

Need More Analysis?

Contact us with your DMPK challenges to see how our team of experts can work with you to solve them.

Ask us how you can get your bioanalytical assessment started today.